a tool for identifying drug-targetable redox-active disulphides

mRNA export factor ICP27 homolog

Intermolecular

Cysteine 188 of HLA class I histocompatibility antigen, A alpha chain and cysteine 302 L

A redox-regulated disulphide may form between cysteine 188 of HLA class I histocompatibility antigen, A alpha chain and cysteine 302 of mRNA export factor ICP27 homolog (164 and 3 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

45

PDB code

Structure name

crystal structure of mhc class i hla-a2 molecule complexed with ebv bmlf1-280-288 nonapeptide t4p variant

Structure deposition date

2010-04-29

Thiol separation (Å)

8

Half-sphere exposure sum ?

73

Minimum pK_a ?

11

% buried

nan

Peptide A name

HLA class I histocompatibility antigen, A alpha chain

Peptide B name

mRNA export factor ICP27 homolog

Peptide A accession

Peptide B accession

Peptide A residue number

188

Peptide B residue number

302

Ligandability

Cysteine 188 of HLA class I histocompatibility antigen, A alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 302 of mRNA export factor ICP27 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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